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L-Glutathione is a naturally derived substance that is a biologically active sulfur amino acid tripeptide compound containing three amino acids: L-Cysteine, L-Glutamic Acid and Glycine

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It also downregulates key extracellular matrix regulators, resulting in improved liver function and histopathology

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Mechanistically, GSH depletion and the decrease in nuclear factor erythroid 2-related factor 2 (Nrf2), glutathione peroxidase 4 (GPx4), and xCT cystineglutamate antiporter (the main component is SLC7A11) are involved in atorvastatin-induced muscular cell ferroptosis and damage