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Phase 1 clinical trials are proceeding now in US adults (first-in-human) followed by dose-escalation among African adults with future age-de-escalation to children with SchistoShield (Sm-p80 expressed in E

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Pathogenesis May arise from fixed macrophages (Kupffer cells) attached to the sinusoidal endothelial cells or from circulating macrophages, unless metastasized from other organs (e.g., skin, uterus)

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