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Hepatocytes perform various functions of the liver, including: fatty acid metabolism, xenobiotic metabolism, retinoid metabolism, and iron homeostasis
Trube G, Rorsman P, Ohno-Shosaku T
IGF-1 is posited to be the main mediator of GHs anabolic actions
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This was corroborated by observations of embryonic lethality in mouse and Caenorhabditis elegans models, with oxidative stress damage shown to be the underlying cause (31)