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With prolonged use, the pituitary's natural GH output decreases a phenomenon documented in endocrinology literature

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52% women) met the studys inclusion criteria and were matched for potential confounders using propensity score matching (n = 15,908 per group)

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Relative cautions include dehydration risk (especially during the switch window), ongoing insulin use requiring dose adjustment, and a history of thyroid nodules requiring surveillance

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