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I., Cuzi, S., Brajsa, K., Mildner, B., Bokuli, A., Situm, K., Perovi, D., Glojnari, I., & Parnham, M

3 were initially assigned a role in maintaining GSH homeostasis ( Arabidopsis , mirroring the function of mammalian CHAC2 (Vernoux et al., 2000)

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In SLE, defective clearance of apoptotic debris [and release of nuclear danger/damage-associated molecular patterns (DAMPs) such as HMGB1] sustains TLR7/9 signaling and type I interferon production, which foster cytotoxic T-cell activation and excessive IFN- responsefeatures characteristic of MAS (6466)

Scientists have also learned how to develop synthetic peptides (lab made versions), which have been designed to mimic or enhance these natural functions in the body

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