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If you take metformin, your physician may recommend: More frequent blood glucose monitoring during the first 2 to 4 weeks of MOTS-c use Starting MOTS-c at a lower dose (2.5 mg rather than 5 mg) Watching for signs of hypoglycemia: shakiness, sweating, confusion, rapid heartbeat Potential metformin dose adjustment as MOTS-c's effects take hold Insulin MOTS-c improves glucose uptake in skeletal muscle independently of insulin

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