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High temperatures could aggravate swelling and pain, slowing the healing process

The practice dates back to the early 1990s, when it was used to safely study how a newly developed drug is absorbed, used and eliminated by the body

It is a requirement in the United States for females with childbearing potential to remain on at least two forms of contraceptives while on [isotretinoin] treatment, Blalock and colleagues wrote in the Journal of Drugs in Dermatology

Liver function tests and metabolic parameters (HbA1c, lipid profile, blood pressure) should be monitored as part of routine care

Avoid caffeine and alcohol initially, as both increase fluid loss and can trigger or worsen loose stools

B12 is important to keep your nervous system working properly