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Inflammatory mediators secreted from these immune cells, such as chemokines, cytokines, adhesion molecules, and reactive oxygen species (ROS), can disturb the functional activity of the vascular endothelium (27), for example, by increasing the proliferation of smooth muscle cells and participating in vascular remodeling (28)
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semaglutide and daily-once oral semaglutide has been approved by USFDA, Health Canada, European Medicines Agency (EMA), and Japanese Health ministry for use in the management of type 2 diabetes
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