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The medication mimics the action of a naturally occurring hormone in your body called GLP-1 (glucagon-like peptide-1)

Multiple factors contribute to this effect

Phase 2 body composition data from the Lancet Diabetes and Endocrinology substudy showed retatrutide achieving fat mass reductions of 15.2% at the 4mg dose, 26.1% at 8mg, and 23.2% at 12mg, while the proportion of lean mass loss relative to total weight loss remained comparable to other GLP-1 compounds

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Strategic Use Strategic use means something very specific: when and how peptides are administered, how they pair with other interventions, and how response is tracked to inform an adaptive personal plan