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While there is no officially established "upper limit" by the FDA, most clinical research suggests that up to 2,000 mg per day is well-tolerated by most adults for short periods

Melanotan I (afamelanotide) is a selective MC1R agonist, whereas Melanotan II is a non-selective agonist active at MC1R, MC3R, MC4R and MC5R

That narrow view is why practices hit a ceiling

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Range of Total Body Weight Loss, Fat Free Mass Loss and Skeletal Muscle Mass Loss by Weight Loss Method