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While peptides are generally less immunogenic than larger proteins, they can still trigger antibody formation in some patients

Additionally, by reducing cravings across substances, GLP-1s have the potential to reduce substance substitution by patients after a successful cessation

19-25 Table 4 provides a summary of key warnings and precautions listed in the labeling of each GLP-1 RA product that should be taken into account when considering use in a patient with T2D

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Furthermore, no convincing evidence currently supports a direct association between gut microbiota composition and the risk of GLP-1 receptor agonist-associated pancreatitis

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