Reprogramming induced pluripotent stem cells in the absence of c-myc for differentiation into hepatocyte-like cells
(1) Parameters measure size, not enlargement (2) Parameters are arbitrary and unsupported (3) CKCSs have normal hearts above VHS 10.5 value (4) Heart-healthy CKCS has a LA/Ao ratio way below 1.6 (5) All Stage B2 sub-groups are lumped together (6) Recommended parameters ignored study's data (7) Study glosses over pimo causing sudden deaths (8) Report hides categories of pimo-caused adverse events (9) Early termination leads to risk of false positives (10) Study ignores contractility and systolic functions (11) Report excludes data of pimo shortening life spans in CHF (12) Report provides no breed-specific information (13) Authors try to defend manufacturer's control over them (14) Report contradicts earlier, misleading press releases But what is most disturbing is what is not in the EPIC Study report
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The choice of colchicine, which is used in pericarditis not something seen in ME/CFS was perhaps a questionable choice, but the other two drugs were wholly in line with what we knew about long COVID in 2021
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reads were trimmed using TrimGalore (48) and aligned to Ensemble hg38 using STAR (49)