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In sleep-stress research, compounds that might normalize this interaction are studied for their potential to break stress-sleep disturbance cycles

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In a mouse model with CD68-driven macrophage depletion, reduced macrophages lead to an imbalance in M1/M2 polarization, with a predominance of M2 type, inducing spontaneous PAH accompanied by PASMCs proliferation (Zawia et al., 2021)

Watanabe, A., Okada, K., Shimizu, Y., Wakabayashi, H., Higuchi, K., Niiya, K.,