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Other in vitro studies suggest that gliadin itself increases intestinal permeability indirectly by promoting the release of zonulin, a protein that induces TJ disassembly and is present in the submucosa of active coeliac patients at concentrations sixfold greater than healthy controls (Fasano et al

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For dietary deficiency, referral to a dietitian can provide valuable guidance on food sources and supplementation strategies

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Due to its dual-peptide profile, it is frequently examined in structured investigations focusing on signalling pathway interaction, recovery-response dynamics, and peptide stability within controlled research environments

Gastroenterology 2023