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Evidence for the involvement of mitochondrial radical generation

summarized the molecular components involved in PANoptosome formation [74]

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15 The gene for glutathione peroxidase-4 is expressed in most tissues, including the brain (Gene Expression Atlas, available at Although the GPX4 gene is highly polymorphic, a limited number of studies 16, 17, 18, 19 have been done to investigate genetic variations within the GPX4 gene that could potentially alter the function of the enzyme

27 Thus, it remains uncertain how vitamin B 12 deficiency may be linked to dementia and what the potential benefits are of treatment with supplementation