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A global reduction in 5-methylcytosine (5mC) levels, indicative of widespread hypomethylation, has been reported in astrocytes of postmortem AD brains, potentially leading to aberrant gene activation 25

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Two emerging pharmacological classes may challenge its risk-reward calculus: Oral GLP-1 agonists (e.g., oral semaglutide, danuglipron): These offer dosing convenience and eliminate injection site reactions, but bioavailability remains problematic (oral semaglutide achieves only 0.41% absorption, requiring daily dosing and strict administration protocols)

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