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adults were living with obesity in 2024, clinical guidelines began recommending GLP-1 initiation within six months of diagnosis rather than after lifestyle failure

In addition, a decrease in androgens/AR level in males with obesity and diabetes is often accompanied by mitochondrial dysfunction, as evidenced by a study showing that male rats experienced myocardial mitochondrial ROS accumulation and enhanced apoptosis after four weeks of castration, whereas these disorders did not occur until week eight in rats of the sham group (69)

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