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Injection site reactions in a smaller subset of patients: Mild redness, localised swelling, or skin sensitivity at the injection site shows up in some patients and typically resolves without needing any intervention as the body settles into regular administration

They used a mouse model of diet-induced obesity and combined metabolomic analyses in BAT and other tissues with stable-isotope tracer studies to answer this question

doi: 10.1126/science.2479986

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3,4 It is estimated that the annual global health care spending on diabetes among people aged 2079 was US$ 966 billion in 2021, and is estimated to reach more than $1054 billion by 2045