As you've just learned, you can't just use IGF all by its lonesome self
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Consequently, Nrf2 can be released and translocate to the nucleus, where it stimulates the transcription of antioxidant and pro-survival genes
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doi: 10.3389/fbioe.2021.677576 Received 07 March 2021 Accepted 12 April 2021 Published 29 April 2021 Volume 9 - 2021 Edited by Zhen Li, AO Research Institute, Switzerland Reviewed by Guangli Suo, Suzhou Institute of Nano-tech and Nano-bionics (CAS), China