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Similar content being viewed by others The approval of GLP-1R agonists for obesity and diabetes mellitus has resulted in higher demand and prescription for these indications, and a GLP-1R agonist is currently in a phase 3 clinical trial in metabolic dysfunction-associated steatohepatitis (MASH) 1

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Cleavage of SDF-1 by DPP-4 results in loss of activity (65), and consistent with this, DPP-4 inhibition in humans has been associated with enhancement of some effects which are associated with SDF-1 [increased levels of circulating endothelial progenitor cells (66) and increased distal tube sodium excretion (64)]

The appetite suppression and metabolic effects can help people stick to reduced-calorie eating patterns that were previously very challenging

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