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Medical Pharmacology Chapter 2: General Principles: Pharmacokinetics Cytochrome P450 Enzyme Induction: Following repeated administration, some drugs increase the amount of P450 enzyme usually by: Increase enzyme synthesis rate (induction) Reduced enzyme degradation rate Cytochrome P450 enzyme inhibition: Certain drugs, by binding to the cytochrome component, act to competitively inhibit metabolism
In addition, radiation-induced gut microbiota dysbiosis is characterized by decreased abundance of beneficial bacteria such as Faecalibacterium prausnitzii and Bifidobacterium bifidum , and increased abundance of detrimental bacteria such as Escherichia-Shigella and Enterococcus
The activity of glucokinase in -cells is controlled by its subcellular localization
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