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Tirzepatide can cause modest increases in heart rate and some patients may experience palpitations, which can be perceived as chest discomfort

Importantly, none of the trials in T1D reported an increase in diabetic ketoacidosis (DKA) a key concern that has limited the use of SGLT2 inhibitors in T1D

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Many symptoms are mild and improve over time, but persistent or worsening symptoms should be discussed with a clinician

However, it should be appreciated that this severe complication is rare and the risk is also less with endoscopy compared with surgical procedures that require general anesthesia (38)

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