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Therapeutic Research Protocol Dose: 5 10 mg (= 100200 clicks) Duration: 6 12 weeks Frequency: Daily Cycle Interval: 4 weeks off before repeating Goal / Description: Higher-dose protocol for models focused on cardiac, renal, or neurodegenerative mitochondrial dysfunction

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An important distinction from the FDA criteria is that the WHO guideline does not extend its recommendation to adults with a BMI between 27 and 30 who have obesity-related conditions

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Ann N Y Acad Sci (2020) 1474:6172

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