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Data availability The DNA methylation data generated in this study for longitudinal semaglutide and placebo samples, have been deposited in the GEO database under accession number: GSE327270

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declares funding to conduct clinical trials from AstraZeneca, Bayer, Boehringer Ingelheim and Novo Nordisk (all to the FIDES Research Foundation) and payment of honoraria for lectures from AstraZeneca, Novo Nordisk, Baxter, Chiesi, ChemoCentrix, Clarion and Boehringer Ingelheim