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To achieve targeted delivery of GLP-1RAs to affected joints, we developed a cartilage-targeting nanoparticle system (GLP-1RAs@NPs-WYRGRL) and integrated it into a methacrylated hyaluronic acid-based microneedle patch (MNs/GLP-1RAs@NPs-WYRGRL)

doi.org/10.1111/dom.15728 4 Tinsley GM, Nadolsky S

Many patients struggle with weight management even when thyroid hormone levels are adequately replaced, suggesting that thyroid dysfunction may trigger persistent metabolic changes

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Yes, GLP-1 receptor agonists commonly cause diarrhea, particularly during dose escalation or at higher maintenance doses

Compounded GLP-1 caution Because branded supply has at times been constrained, compounded GLP-1 products proliferated and they sit in a far more complicated and shifting regulatory position than the FDA-approved branded medications