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Women have reported changes in menstrual cycles , though the exact relationship is still being studied

The authors note that GHSs likely behave as functional somatostatin antagonists while enhancing GHRH-secreting neurons, that their GH-releasing effect is independent of gender but undergoes marked age-related variation, and that their activity is not fully specific for GH: they also produce slight prolactin release and, in Cushing disease, ACTH and cortisol responses

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Owing to the heterogeneous characterization, IBS poses a significant medical burden, and considerably impact patient quality of life of patients with IBS (Enck et al., 2016

It may be harmful to the teeth

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