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These simple adjustments often improve gastrointestinal tolerance substantially

C., Park, Y., and Cha, Y

Therefore, it remains unclear whether the reduction of steatosis observed in animal and human trials in response to treatment with GLP-1R agonists results from direct activation of hepatic GLP-1R or the indirect impact such as weight loss, increased insulin sensitivity, brain-liver signals such as brain leptin 51 , or other hormonal signals that these agonists might trigger 14

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Rodriguez-Colman MJ, Dansen TB, Burgering BMT (2024) FOXO transcription factors as mediators of stress adaptation

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