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RS brain does not display obvious manifestations of structural neuronal or glial damage [370, 371]

Phase III Trial of Sunitinib in Combination with Capecitabine versus Capecitabine Monotherapy for the Treatment of Patients with Pretreated Metastatic Breast Cancer

Key Causes Include: 1

Therefore, further studies are required to determine their clinical efficacy

Although this condition may improve once the medication is discontinued, it may still leave some lasting effects

In addition, GPX4 inhibitors remain challenging to use in vivo owing to their poor bioavailability, and pharmacological inhibition of GPX4 carries a substantial risk of systemic toxicity, as demonstrated in GPX4 knockout mouse models 25,26,27 Thus, modulating the CoQ 10 redox cycle, either by inhibiting ubiquinol (CoQ 10 H 2 , reduced) formation or altering oxidoreductase activity, has emerged as an alternative therapeutic strategy for ferroptosis-based cancer therapy