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HopZ4 from Pseudomonas syringae, a member of the HopZ type III effector family from the YopJ superfamily, inhibits the proteasome in plants
Key findings from the trial (Jastreboff et al., NEJM 2023) included: Placebo group : Mean body weight reduction of approximately 2.1% from baseline at 48 weeks
Emery, E
Gimpl G Transport of Plasma Membrane-Derived Cholesterol and the Function of Niemann-Pick C1 Protein
Liraglutide has the most robust evidence base specifically in NASH, given the LEAN trial results
Exclusion criteria observed in Phase 2 trials included individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, given the class-level concern with GLP-1 receptor agonists and C-cell tumours in rodent models [8]
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