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We determined experimentally that pre-stroke weight loss by GLP-1R/NPY2R activation strongly improves stroke recovery in diabetes

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Higher doses increased the risk of constipation

Metabolic stress increases

The substrate-binding site recognizes the consensus sequence LXGGX (the amino acid residues of the substrate are numbered P4P3P2P1P1P2 around the cleavage site, denoted by the downwards arrow)