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Specifically, the cytokine TGF- hinders the production of GSH, causing a chain reaction: lower GSH results in heightened free radicals, exacerbated by an increase in proinflammatory cytokines

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The redundant radicals begin to damage the biological macromolecules in cells and influence the cell function

Their hydrophilicity prevents efficient transcellular transport (crossing through cell membranes), while their size prevents efficient paracellular transport (passing between cells)

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