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Incorporating beetroot or nitrate-rich vegetables may provide mild symptomatic relief, but as with all dietary strategies, this should complement (not replace) medical management

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Parkin degradation may be mediated in conjunction with increases in LC3 expression, which may be affected by differences in cell types or copper ion carriers

Additionally, PDOs have been widely used for predicting drug sensitivity in CRC and can be combined with mitochondrial function dyes (e.g., JC-1, TMRM) to perform metabolic dependency-based individual screening [178]

The associated models have been deposited to the Protein Data Bank ( with accession codes 9WAG, 9WAH, and 9WAI

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