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Daily ODTs may still be useful for selected patients, especially when needle avoidance is the primary barrier to starting treatment

5Halliwell B, Gutteridge JMC

This hypertrophic shift recapitulates features of endochondral ossification and contributes to cartilage calcification, tidemark duplication, and eventual osteophyte formation at joint margins (Rim et al., 2020)

Additional downstream mediators include ErbB ligands such as epiregulin and vasoactive intestinal polypeptide (VIP) (68)