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Diabetes (2009) 58(11):246475

Hyperglycemia-driven signaling bridges between diabetes and cancer

demonstrated that cardiac GLP-1R expression is localized in cardiac atria and that GLP-1R activation promotes secretion of atrial natriuretic peptide (ANP) and increases BP [64]

This means drug release depends entirely on the gradual degradation of the antibody in lysosomes, resulting in minimal free drug in circulation and lower systemic toxicity risk