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In cases where a phosphorylated peptide mapped to multiple protein isoforms derived from the same gene, all mapped isoforms were designated as the substrates of the specific kinase

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This safety feature reduces hypoglycemia risk compared to insulin or sulfonylurea medications

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With regard to Wnt/-catenin signaling, the electrophilic ,-unsaturated ketone moiety of 4-HNE reacts with the side chain of -catenin to form covalent adducts that alter the turnover of -catenin

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