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44 The longer aliphatic chain in semaglutide, a long-acting formulation based on the structure of liraglutide, enhances hydrophobicity by altering the DPP-4 enzyme hydrolysis site with polyethylene glycol (PEG), allowing it to strongly bind to albumin

The only safeguards are strict adherence to reconstitution protocols, refrigerated storage at 28C, protection from light, and discarding the solution after 28 days regardless of appearance

Avoid injecting into areas with visible bruising, inflammation, or skin lesions, as these sites have compromised barrier function

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10.1186/s13048-022-01032-x 143 YaoY.ChenT.WuH.YangN.XuS