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Less Common but Serious Risks Pancreatitis (inflammation of the pancreas) Gastroparesis (severely delayed stomach emptying) Gallbladder complications, including gallstones Bowel obstruction (rare but documented) Thyroid Considerations All GLP-1 receptor agonists carry a boxed warning based on animal studies showing thyroid C-cell tumors in rodents

However, researchers also observed less-documented complaints, including fatigue, temperature sensitivity (chills or hot flashes), and menstrual changes

Due to limited human data, the risk to the developing foetus cannot be ruled out

Additional Considerations Lip Adhesion can be indicated for wide clefts or bilateral clefts with a protruding premaxilla

Patients should be seen or contacted within 2-4 weeks of initiation to assess tolerability, review lifestyle adherence, and address concerns

Other studies suggest that there may be a link between caffeine consumption and hot flashes, but the evidence is mixed