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Microbiome composition and its impact on the development of allergic diseases

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Consistent with this finding, single-nuclei RNA-sequencing (snRNA-seq) revealed that GIPR agonism and antagonism have opposing effects in the brain, with GIPR antagonism but not agonism mimicking the transcriptional responses of GLP-1R agonism in the dorsal vagal complex of the hindbrain (DVC), and with GIPR antagonism and GLP-1R agonism both modulating DVC gene programmes implicated in synapse formation and neuronal plasticity

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Flavonols Flavonols include more than 60 types of aglycones, among which quercetin and kaempferol are widely distributed, although rutin and myricetin are also common