However, reported side effects are consistent with its incretin-based mechanism of action
The opportunity: eating less becomes much easier
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monitoring may be required Polycythemia vera: Correcting B12 deficiency may unmask underlying polycythemia Masking folate deficiency: B12 supplementation can mask the hematologic signs of folate deficiency while allowing neurological damage to progress Allergic reactions: Rare hypersensitivity reactions have been reported, including anaphylactic shock with cyanocobalamin Common Side Effects Mild diarrhea Injection site reactions: pain, swelling, itching Feeling of generalized body swelling Mild headache Temporary reddish urine (normal B12 is water-soluble and excreted) Seek Medical Attention For Signs of serious allergic reaction: rash, hives, facial swelling, difficulty breathing Chest pain or irregular heartbeat Signs of low potassium: muscle cramps, weakness, irregular heartbeat Vision changes (especially if you have Lebers disease) Drug Interactions Chloramphenicol: May antagonize the hematopoietic response to B12 Metformin, proton pump inhibitors, H2 blockers: Can reduce B12 absorption (these are reasons to use injectable B12 instead of oral) Nitrous oxide: Can inactivate B12 in the body Use in Pregnancy and Breastfeeding B12 is generally considered safe during pregnancy and breastfeeding when used at appropriate doses

In the beginning of the year, this is always more pronounced, because each insurance changes what they're doing for coverage. Gastrointestinal side effects can also make it tough to stick with GLP-1s, says Dr
One A 2021 review of research suggests that a combination of protein and calcium may help trigger increased GLP-1 secretion