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In contrast, the pull model postulates that consumption of food with a high glycemic load stimulates insulin, which alters fuel partitioning, inhibiting mitochondrial respiration and fatty acid utilization (78, 79) and promoting fat deposition into adipose tissue, stimulating hunger and further consumption

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Oral Isotretinoin Isotretinoin is a retinoid widely used in the treatment of acne and many other skin conditions

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Metformin is a diabetes medication sometimes used off-label for weight loss, especially in patients with insulin resistance or prediabetes