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The antioxidant activity of saffron is mainly due to crocin, and the synergistic effect of crocin and crocetin enhances oxygen diffusion and enhances ocular blood flow in the retina and choroid, which are crucial in the disease [230]

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Carnitine deficiency has been widely reported in patients with epilepsy being treated with valproic acid and there have been reports that carbamazepine and phenobarbital may also deplete carnitine levels especially if used in combination with valproic acid