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(35) Conclusion GLP-1 receptor agonists are becoming integral to obesity and diabetes management, with significant implications for orthopedic surgery

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These agents differ in their half-life and route of administration, with both subcutaneous and oral formulations available, offering flexibility in therapeutic application

Start by speaking to your GP, who can assess your individual circumstances and refer you to appropriate NHS weight management services, including structured lifestyle programmes or specialist tier 3 or tier 4 services for complex cases

Fad diets and excessive exercise may lead to temporary weight loss but often do not offer a long-term solution for chronic weight management

Animal models show compensatory mechanisms by which, in absence of a major incretin axis, other minor pathways are promoted in the -cells to maintain their metabolic activity