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In line with laboratory-controlled studies demonstrating altered food preferences, the reduction in food intake among GLP-1 users is disproportionately associated with decreased consumption of processed foods, while intake of fruits and vegetables has increased overall

While it is well-established that intestinal GLP-1 cells can exert influence through paracrine mechanisms, recent evidence suggests the possible existence of synaptic-like connections between GLP-1 cells and peripheral neurons, including those of the vagus nerve

Naunyn-Schmiedebergs Archiv Pharmacol

** Based on the treatment regimen estimand: treatment effect regardless of whether patients stayed on treatment or took other glucose-lowering therapies

Dose in units = (Dose in mg / Concentration in mg/mL) x 100 That is it

The approval does not yet extend to the weightloss indication, for which regulatory clearance is still awaited