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Drug-induced GR inhibition : Several medications, including antimalarials, antipsychotics, and certain chemotherapeutic agents, can inhibit GR activity

once daily) for 15 days, and a single dose of Methotrexate (2 mg/kg, i.p

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consider tolerance and side effects

Statistical analysis All data were expressed as the means SD and were analyzed using an analysis of variance (ANOVA) followed by Tukeys test (* P 0.05, ** P 0.01, *** P 0.001) for post-hoc comparisons

Steatosis, congestion, and necrosis were graded separately over the entire submitted tissue as previously described (11)