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Given the relatively small size of SR18, the estimated binding free energy for SR18GLP-1R complex is noted to be 98.79 8.77 kcal/mol compared to 167.22 16.20 kcal/mol observed for GLP-1GLP-1R complex, which suggests that SR18 strongly binds to GLP-1R

JACC: Heart Fail 11(6):724726