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5.2 Reduction of oxidative stress and endoplasmic reticulum stress Chronic hyperglycemia and endothelial activation drive excessive generation of ROS, promoting mitochondrial dysfunction, endothelial apoptosis, and reduced NO bioavailability

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This process involves GPER-G protein interactions that amplify downstream signaling, driving cell proliferation and differentiation

Feb 26 2022;10(6):1815-1825

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