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Expect a gradual trend, especially as doses are increased slowly to improve tolerability

Further, GLP-1RAs promote VSMC redifferentiation via AMPK/SIRT1/forkhead box O (FOXO3a) pathways, where the expression of contractile VSMCs markers (SM22 and Calponin) is increased [125]

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Foods such as avocados, nuts (almonds, walnuts), seeds (chia, hemp), and olive oil stimulate L-cell activity