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Missing multiple consecutive weeks means semaglutide levels in your system have dropped substantially, so jumping back in at your previous dose could cause more side effects than if youd maintained consistent dosing

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Nevertheless, a retrospective analysis of T2DM treatment in UK showed that the mean time to add a second oral agent in patients with A1c above 7.0, 7.5 and 8.0%, was 2.9, 1.9 and 1.6 years, respectively