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Frontiers In Nutrition

While metformin and lifestyle modification are the preferred first-line treatments in patients with T2DM and an elevated HbA1c, GLP-1 RAs are now a preferred second-line therapy and are even recommended first-line agents in patients with known atherosclerotic cardiovascular disease, high cardiovascular risk, or chronic kidney disease

This corresponded to a NNH of 1,198, indicating that approximately one additional case of psoriasis would occur for every 1,200 patients treated with GLP-1 RAs instead of DPP-4is

Gallbladder Problems: Rapid weight loss, often experienced with GLP-1 drugs, can contribute to gallstone formation and gallbladder issues

Plasma Donation and Type 2 Diabetes Many people take GLP-1 medications to manage Type 2 diabetes

Carrying excess weight can lead to joint pain, limited mobility, and difficulty performing everyday activities