This growth is driven by an increased demand for weight-loss agents and the need to control the global obesity epidemic. The market is currently dominated by Novo Nordisk and Eli Lilly and their respective glucagon-like peptide-1 (GLP-1) agonists, semaglutide and tirzepatide
By controlling parameters such as sheet size, oxygen functionalization density, interlayer spacing, and hybridization with complementary nanomaterials, researchers can design GO-based materials with tailored mechanical performance that simultaneously meet sustainability and multifunctionality criteria
In terms of efficacy, GH and IGF-1 both stimulated linear growth but some variables including the greater growth deficit in infants with Laron syndrome than those with isolated growth hormone deficiency, insufficient IGF-1 dose, or the IGF-1 dependency on the GH-linked stem cell population of prechondrocytes made GH more efficient in terms of linear growth stimulation (170, 171)
Within the GLP-1 RA category, liraglutide emerged as the top-performing medication for the management of overweight and obesity
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